Metronidazole dose and side effects
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Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner. Do not give your pet two doses at once. Its anti-inflammatory action within the gastrointestinal tract may be related to suppression of some parts of the immune system.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. The proper dosage of metronidazole for dogs depends on which condition is being treated.
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250 mg three times daily for seven consecutive days. Neurological symptoms might include seizures, staggering, stiffness, or strange movements and behavior. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Metronidazole crosses the placental barrier and its effects on the human fetal organogenesis are not known. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Twentyfifth Informational Supplement, CLSI document M100S25.
Some rare, more serious side effects that usually only occur with long-term use include low blood platelet count, liver damage, insomnia, or neurological conditions related to toxicity. Take this medication for the full prescribed length of time. Pediatric Use Safety and effectiveness in pediatric patients have not been established, except for the treatment of amebiasis. Metronidazole is an antibiotic prescribed by veterinarians for dogs to treat diarrhea, inflammation of the large intestine, and other bacterial and parasitic infections such as Giardia.
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Can Growing up with a Cat Prevent Asthma in Children? Is It a Cold, Strep, or Tonsillitis? Don’t take more or less metronidazole than is recommended. Study: Nearly Half of All Pet Parents Don’t Have Car Safety Gear for Their Dogs When it comes to traveling in a car with your dog, safety should be paramount for you both. This list is not complete and other drugs may interact with metronidazole. Your vet can give you advice on how to properly measure the dose for your dog.
DRUG INTERACTIONS Disulfiram Psychotic reactions have been reported in alcoholic patients who are using metronidazole and disulfiram concurrently. Vaccines are not a replacement for vigilance, but they are an important part of your pet’s healthcare. INDICATIONS Symptomatic Trichomoniasis FLAGYL is indicated for the treatment of T. Convulsive seizures have been reported in patients treated with metronidazole. Its use should be reserved for the conditions described in the INDICATIONS AND USAGE section below. Your pharmacist can provide more information about metronidazole.
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You may have unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. Asymptomatic Trichomoniasis FLAGYL is indicated in the treatment of asymptomatic T. The average elimination halflife of metronidazole in healthy subjects is eight hours. The information within the Reviews and FAQ tabs is proprietary to Everyday Health. In amebic liver abscess, FLAGYL therapy does not obviate the need for aspiration or drainage of pus.
Quality Control Standardized susceptibility test procedures require the use of laboratory controls to monitor and ensure the accuracy and precision of supplies and reagents used in the assay, and the techniques of the individuals performing the test. Treatment Of Asymptomatic Sexual Partners T. It colonizes and reproduces in the small intestine and causes giardiasis. This includes prescription, over-the-counter, vitamin, and herbal products. Typically these occur when pets ingest more than the recommended dose or when they are on long-term therapy, particularly if they are debilitated or suffer from liver dysfunction. Metronidazole is an antibiotic, which works by killing bacteria in your body.
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Patients with Crohn’s disease are known to have an increased incidence of gastrointestinal and certain extraintestinal cancers. A maximum of 4 g should not be exceeded during a 24-hour period. Oral metronidazole has been studied as a radiation sensitizer in the treatment of malignant tumors. Carcinogenesis, Mutagenesis, Impairment Of Fertility Tumors affecting the liver, lungs, mammary, and lymphatic tissues have been detected in several studies of metronidazole in rats and mice, but not hamsters. 5000 pregnant women who used metronidazole during pregnancy. Renal Impairment Patients with end-stage renal disease may excrete metronidazole and metabolites slowly in the urine, resulting in significant accumulation of metronidazole metabolites.
Check the labels of any medicines or food products you use to make sure they do not contain alcohol. Take exactly as prescribed by your doctor. Symptoms can occur within hours of dose administration and generally resolve after metronidazole therapy is discontinued. The usual adult oral dosage is 7. Higher doses may be given once daily, while lower doses are generally given twice daily.
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Let us know in the comments below! Metronidazole may also be used for purposes not listed in this medication guide. Cardiovascular Flattening of the T-wave may be seen in electrocardiographic tracings. And what sorts of ailments might it treat?
Your dose will depend on your medical condition and your response to treatment. INTRA-ABDOMINAL INFECTIONS, including peritonitis, intraabdominal abscess, and liver abscess, caused by Bacteroides species including the B. Warfarin And Other Oral Anticoagulants Metronidazole has been reported to potentiate the anticoagulant effect of warfarin and other oral coumarin anticoagulants, resulting in a prolongation of prothrombin time.
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Busulfan Metronidazole has been reported to increase plasma concentrations of busulfan, which can result in an increased risk for serious busulfan toxicity. Psychotic Reaction With Disulfiram Use of oral metronidazole is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Total and differential leukocyte counts should be made before and after retreatment. Do not crush, chew, or break an extended-release tablet. The tablets can be taken with food or a glass of milk to prevent upset stomach. Patients Undergoing Hemodialysis Hemodialysis removes significant amounts of metronidazole and its metabolites from systemic circulation.
For protozoal parasites Standardized tests do not exist for use in clinical microbiology laboratories. Unnecessary use of the drug should be avoided. Metronidazole should not be administered concomitantly with busulfan unless the benefit outweighs the risk. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. To be sure this medication is not causing harmful effects, your blood may need to be tested often. Interaction With Alcohol Use of oral metronidazole is associated with a disulfiram-like reaction to alcohol, including abdominal cramps, nausea, vomiting, headaches, and flushing.
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Drug Resistance A potential for development of resistance exists against metronidazole. Where can I get more information? Healthy Weight Calculator Use our handy tool to help determine whether your pet is at an ideal weight or needs a change in diet and lifestyle. Tablets and capsules are to be kept in a tightly sealed container at room temperature and protected from heat and light. Your liver function may also need to be tested. SKIN AND SKIN STRUCTURE INFECTIONS caused by Bacteroides species including the B.
Reproduction studies have been performed in rats, rabbits, and mice at doses similar to the maximum recommended human dose based on body surface area comparisons. Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, PA 19087 USA, 2012. Peripheral neuropathy, mainly of sensory type has been reported and is characterized by numbness or paresthesia of an extremity. Distribution Metronidazole is the major component appearing in the plasma, with lesser quantities of metabolites also being present. The dosage for metronidazole in dogs and cats varies depending on its intended use and the specifics of a patient’s case. Antibiotic medicines can cause diarrhea, which may be a sign of a new infection.
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The dosage regimen should be individualized. Metronidazole’s mechanism of action is not fully understood. Side effects of metronidazole in dogs are rare, and the drug is considered to be quite safe when administered properly.
Do not take extra medicine to make up the missed dose. These pills are extended-release for humans, but dogs have a shorter digestive tract and may only partially digest the medication before passing it. In the case of Giardia, 7 to 11 mg per pounds is often prescribed to be given every once every 24 hours, but the dosage can go as high as 29. CLINICAL PHARMACOLOGY Absorption Disposition of metronidazole in the body is similar for both oral and intravenous dosage forms.
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Candida which may occur during therapy. Kidney Diets for Cats: What to Look for Symptoms and treatment for kidney disease vary depending the specifics of the case, but oftentimes, a diet change can help. Do not drink alcohol while you are taking metronidazole and for at least 3 days after you stop taking it.
Clostridium species, Peptococcus species, Peptostreptococcus species, and Fusobacterium species. Tell your doctor about all medications you use. Aseptic meningitis Cases of aseptic meningitis have been reported with metronidazole. Lithium In patients stabilized on relatively high doses of lithium, short-term metronidazole therapy has been associated with elevation of serum lithium and, in a few cases, signs of lithium toxicity. BACTERIAL SEPTICEMIA caused by Bacteroides species including the B. INFECTIONS, including meningitis and brain abscess, caused by Bacteroides species including the B.